【著書】
体にやさしい抗がん漢方薬：（福田一典 著）主婦の友出版社2001年
癌予防のパラダイムシフト-現代西洋医学と東洋医学の接点-：（福田一典 著）医薬ジャーナル社1999年
門脈圧亢進症の病理 - 肝内血管系の変化を中心に -：（共同執筆：中島敏郎、鹿毛政義、福田一典、長崎嘉和）医学書院、1996年
【総説】
癌の未病対策−東洋医学的視点から（福田一典）医学のあゆみ、第196巻10号（2001）
Modulation of nitric oxide production by crude drugs and Kampo medicines.
(Kazunori Fukuda) Journal of Traditional Medicines,
15, 22-32 (1998)
生体応答と漢方薬の作用 - 特に酸化的ストレスに対する作用について - (福田一典、鈴木理恵、佐登宣仁、淀井淳司)Progress in Medicine, 16 , 231-236
(1996)
和漢薬のアポトーシス調節作用 (山本雅浩、三浦尚子、福田一典、小松靖弘)
漢方と最新治療、5,185-190 (1996)
【原著論文（英文）】
Suppression of promoter-dependent transcriptional activity of inducible
nitric oxide synthase by sodium butyrate in colon cancer cells. (Sasahara Y,
Mutoh M, Takahashi M, Fukuda K, Tanaka N, Sugimura T,
Wakabayashi K.) Cancer Lett. 28;177:155-161 (2002)
The herbal medicine shosaiko-to exerts different modulating effects on lung
local immune responses among mouse strains. (Ohtake N, Nakai Y, Yamamoto M,
Ishige A, Sasaki H, Fukuda K, Hayashi S, Hayakawa S.)
Int Immunopharmacol. 2:357-366 (2002)
Detection and cloning of a protein recognized by anti-human prostate-specific
antigen (PSA) antibody in the rat ventral prostate. (Onozawa M, Fukuda K, Watanabe M, Ohtani M, Akaza H, Sugimura T,
Wakabayashi K.) Jpn J Cancer Res. 92:863-868 (2001)
Anti-tumor effect of gallic acid on LL-2 lung cancer cells transplanted in
mice.
(Kawada M, Ohno Y, Ri Y, Ikoma T, Yuugetu H, Asai T, Watanabe M, Yasuda
N, Akao S, Takemura G, Minatoguchi S, Gotoh K, Fujiwara H, Fukuda K.)Anticancer Drugs. 12:847-852 (2001)
Treatment with sheng-mai-san reduces myocardial infarct size through
activation of protein kinase C and opening of mitochondrial KATP channel. (Wang
N, Minatoguchi S, Uno Y, Arai M, Hashimoto K, Hashimoto Y, Yamaguchi K, Fukuda K, Akao S, Fujiwara H. ) Am J Chin Med. 29:367-375
(2001)
Inhibition by costunolide of phorbol ester-induced transcriptional activation
of inducible nitric oxide synthase gene in a human monocyte cell line THP-1.
(Fukuda K, Akao S, Ohno Y, Yamashita K, Fujiwara H.)
Cancer Lett. 164:7-13 (2001)
Characterization of ultrastructure and its relation with DNA fragmentation in
Fas-induced apoptosis of cultured cardiac myocytes.(Takemura G, Kato S, Aoyama
T, Hayakawa Y, Kanoh M, Maruyama R, Arai M, Nishigaki K, Minatoguchi S, Fukuda K, Fujiwara T, Fujiwara H.) J Pathol. 193:546-556
(2001)
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity
in colon cancer cells by chemopreventive agents with a resorcin-type structure.
(Mutoh M, Takahashi M, Fukuda K, Matsushima-Hibiya Y,
Mutoh H, Sugimura T, Wakabayashi K) Carcinogenesis 21:959-963 (2000)
Suppression by Flavonoids of Cyclooxygenase-2 Promoter-dependent
Transcriptional Activity in Colon Cancer Cells: Structure-Activity Relationship.
(Mutoh M, Takahashi M, Fukuda K, Komatsu H, Enya T,
Matsushima-Hibiya Y, Mutoh H, Sugimura T, Wakabayashi K) Jpn J Cancer Res
91:686-691 (2000)
Inhibition by parthenolide of phorbol ester-induced transcriptional
activation of inducible nitric oxide synthase gene in a human monocyte cell line
THP-1.(Fukuda K, Hibiya Y, Mutoh M, Ohno Y, Yamashita
K, Akao S, Fujiwara H.) Biochem Pharmacol 60:595-600 (2000 )
Modulation of lung local immune responses by oral administration of a herbal
medicine Sho-saiko-to.(Ohtake N, Suzuki R, Daikuhara H, Nakai Y, Yamamoto M,
Amagaya S, Ishige A, Sasaki H, Komatsu Y, Fukuda K,
Hayashi S) Int J Immunopharmacol 22:419-430 (2000)
Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and
suppression of Fas-induced lethal liver apoptosis in mice. (Yamamoto M, Miura N,
Ohtake N, Amagaya S, Ishige A, Sasaki H, Komatsu Y, Fukuda
K, Ito T, Terasawa K) Gastroenterology 118:380-389 (2000)
Gallic acid induces vascular smooth muscle cell death via hydroxyl radical
production. (Qiu X, Takemura G, Koshiji M, Hayakawa Y, Kanoh M, Maruyama R, Ohno
Y, Minatoguchi S, Akao S, Fukuda K, Fujiwara T,
Fujiwara H.)
Heart Vessels.15:90-99 (2000)
Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2
activity and azoxymethane-induced aberrant crypt foci development in
rats.(Fukutake M, Miura N, Yamamoto M, Fukuda K,
Iijima O, Ishikawa H, Kubo M, Okada M, Komatsu Y, Sasaki H, Wakabayashi K,
Ishige A, Amagaya S) Cancer Lett 157:9-14 (2000)
Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL)
in hearts with dilated cardiomyopathy: not apoptosis but DNA repair. (Kanoh M,
Takemura G, Misao J, Hayakawa Y, Aoyama T, Nishigaki K, Noda T, Fujiwara T,
Fukuda K, Minatoguchi S, Fujiwara H) Circulation 99,
2757-2764 (1999)
Apoptosis and overexpression of bax protein and bax mRNA in smooth muscle
cells within intimal hyperplasia of human radial arteries : analysis with
arteriovenous fistulas used for hemodialysis. (Hayakawa Y, Takemura G, Misao J,
Kanoh M, Ohno M, Ohashi H, Takatsu H, Ito H, Fukuda
K, Fujiwara T. Minatoguchi S, Fujiwara H. )Arterioscler Thromb Vasc Biol
19, 2066-2077 (1999)
Induction of apoptosis by gallic acid in lung cancer cells. (Ohno Y, Fukuda K, Takemura G, Toyota M, Watanabe M, Yasuda N,
Xinbin Q, Maruyama R, Akao S, Gotou K, Fujiwara T, Fujiwara H) Anticancer Drugs
10:845-851 (1999)
Acquisition of resistance to apoptosis and necrosis by Bcl-xL over-expression
in rat hepatoma McA-RH8994 cells. (Fukuda K, Yamamoto
M.) Journal of Gastroenterology and Hepatology 14, 682-690 (1999)
Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat
hepatoma cells. (Fukuda K.) International Journal of
Biochemistry & Cell Biology 31, 519-529 (1999)
Induction of tissue transglutaminase expression by propionate and n-butyrate
in colon cancer cell lines. (Fukuda K) Journal of
Nutritional Biochemistry 10, 397-404 (1999)
Effects of a soybean isoflavone mixture on carcinogenesis in prostate and
seminal vesicles of F344 rats. (Onozawa M, Kawamori T, Baba M, Fukuda K, Toda T, Sato H, Ohtani M, Akaza H, Sugimura T,
Wakabayashi K. ) Japanese Journal of Cancer Research 90, 393-398 (1999)
Inhibition of activator protein 1 activity by berberine in human hepatoma
cells. (Fukuda K, Hibiya Y, Mutoh M, Koshiji M, Akao
S, Fujiwara H) Planta Medica 65,381-383 (1999)
Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human
colon cancer cells. (Fukuda K, Hibiya Y, Mutoh M,
Koshiji M, Akao S, Fujiwara H.) Journal of Ethnopharmacology 66, 227-233
(1999)
Transcriptional induction of Bcl-xL gene by glucocorticoids and a
mineralcorticoid aldosterone in rat hepatoma cell line McA-RH8994. (Fukuda K, Yamamoto M) Hepatology Research 13, 160-169
(1999)
Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2,
on azoxymethane-induced colon carcinogenesis in mice. (Fukutake M, Nakatsugi S,
Isoi T, Takahashi M, Ohta T, Mamiya S, Taniguchi Y, Sato H, Fukuda K, Sugimura T, Wakabayashi K.) Carcinogenesis
19,1939-1942 (1998)
Inhibition by 1'-acetoxychavicol acetate of lipopolysaccharide- and
interferon-gamma-induced nitric oxide production through suppression of
inducible nitric oxide synthase gene expression in RAW264 cells. (Ohata T, Fukuda K, Murakami A, Ohigashi H, Sugimura T, Wakabayashi
K.) Carcinogenesis 19, 1007-1012 (1998)
Inhibition by dexamethasone of transforming growth factor beta1-induced
apoptosis in rat hepatoma cells: a possible association with Bcl-xL induction.
(Yamamoto M, Fukuda K, Miura N, Suzuki R, Kido T,
Komatsu Y.) Hepatology 27, 959-966 (1998)
Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on
azoxymethane-induced aberrant crypt foci formation in rat colon. (Fukutake M,
Yokota S, Kawamura H, Iizuka A, Amagaya S, Fukuda K,
Komatsu Y.) Biol Pharm Bull 21, 814-817 (1998)
Effects of soybean isoflavones on cell growth and apoptosis of the human
prostatic cancer cell line LNCaP. (Onozawa M, Fukuda
K, Ohtani M, Akaza H, Sugimura T, Wakabayashi K. ) Japanese Journal of
Clinical Oncology 28, 360-363 (1998)
Transcriptional induction of Bcl-xL gene by glucocorticoids and a
mineralcorticoid aldosterone in rat hepatoma cell line McA-RH8994. (Fukuda K, Yamamoto M. ) Hepatology Research 13, 160-169
(1998)
Beta-catenin is frequently mutated and demonstrates altered cellular location
in azoxymethane-induced rat colon tumors. (Takahashi M,
Fukuda K, Sugimura T, Wakabayashi K) Cancer Res ,58, 42-46 (1998)
Immunohistochemical measurement of cell proliferation as replicative DNA
synthesis in the liver of male Fischer 344 rats following a single exposure to
nongenotoxic hepatocarcinogens and noncarcinogens. (Ohtsuka M, Fukuda K, Yano H, Kojiro M) Exp Toxicol Pathol 50:13-17
(1998)
Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
(PHIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid
(DHA). (Takahashi M, Totsuka Y, Masuda M, Fukuda K,
Oguri A, Yazawa K, Sugimura T, Wakabayashi K.) Carcinogenesis 18:1937-1941
(1997)
Suppression of azoxymethane-induced rat colon carcinoma development by a fish
oil component, docosahexaenoic acid (DHA). (Takahashi M, Fukutake M, Isoi
T, Fukuda K, Sato H, Yazawa K, Sugimura T,
Wakabayashi K.) Carcinogenesis 18, 1337-1342, (1997)
Inhibition of thymocyte apoptosis by berberine. (Miura N, Yamamoto M, Ueki T,
Kitani T, Kukuda K, Komatsu Y.) Biochemical
Pharmacology 53, 1315-1322 (1997)
Increased expression of inducible and endothelial constitutive nitric oxide
synthases in rat colon tumors induced by azoxymethane. (Takahashi M, Fukuda K, Ohata T, Sugimura T, Wakabayashi K.) Cancer
Research 57, 1233-1237 (1997)
Suppression of intestinal polyp development by nimesulide, a selective
cyclooxygenase-2 inhibitor, in Min mice. (Nakatsugi S, Fukutake M, Takahashi M,
Fukuda K, Isoi T, Taniguchi Y, Sugimura T,
Wakabayashi K.) Jpn. J. Cancer Res., 88: 1117-1120, (1997)
Suppression of nitric oxide production in lipopolysaccharide-stimulated
macrophage cells by w3 polyunsaturated fatty acids. (Ohata T, Fukuda K, Takahashi M, Sugimura T, Wakabayashi K.) Jpn. J.
Cancer Res. 88, 234-237 (1997)
An alpha-fetoprotein-producing human gallbladder carcinoma cell line (KMG-C)
shows more aggressive biological behavior than an
alpha-fetoprotein-non-producing cell line. (Maruiwa M, Yano H, Fukuda K, Ogasawara S, Hisaka T, Yamaguchi R, Kojiro M.)
International Journal of Oncology. 8; 1179-1188 (1996)
The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by
transforming growth factor b1. (Yamamoto M, Ogawa K, Morita M, Fukuda K and Komatsu Y.) Hepatology, 23; 552-559 (1996)
Expression of Fas and anti-Fas-mediated apoptosis in human hepatocellular
carcinoma cell lines. (Yano H, Fukuda K, Haramaki M,
Momosaki S, Ogasawara S, Higaki K, Kojiro M.) Journal of Hepatology. 25; 454-464
(1996)
Inhibitory effects of herbal medicines on nitric oxide production in
macrophage and hepatoma cell lines induced by inflammatory stimuli. (Suzuki R,
Kido T, Miura N, Yamamoto M, Komatsu Y, Fukuda K)
Journal of Traditional Medicines, 13; 165-172 (1996)
Expression of CD44 in human hepatocellular carcinoma cell lines. (Haramaki M.
Yano H. Fukuda K. Momosaki S. Ogasawara S. Kojiro M.
) Hepatology. 21(5):1276-84 (1995)
Effects of nine active ingredients in Chinese herbal medicine Sho-saiko-to on
2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide mutagenicity. (Ohtsuka M, Fukuda K, Yano H, Kojiro M.) Japanese Journal of Cancer
Research, 86; 1131-1135 (1995)
Increased production of tumor necrosis factor and interleukin-1b in the
murine lung by Sho-saiko- to and interferon a/b. (Fukuda
K, Suzuki R, Kido T, Miura N, Yamamoto M, Komatsu Y.) Journal of
Traditional Medicines, 12; 142-146 (1995)
Synergistic effects of Sho-saiko-to and interferon-a/b on in vivo nitric
oxide generation in mice. (Fukuda K, Suzuki R, Kido
T, Miura N, Yamamoto M, Komatsu Y.) Journal of Traditional Medicines, 12;
137-141 (1995)
Increase in nitric oxide synthase and cyclic GMP in vascular smooth muscle
cells by treatment with aqueous extracts of Astragali radix, Ginseng radix and
Scutellariae radix. (Fukuda K, Kido T, Miura N,
yamamoto M, Komatsu Y.) Journal of Traditional Medicines, 12; 38-44 (1995)
The herbal medicine sho-saiko-to inhibits proliferation of cancer cell line
by inducing apoptosis and arrest at G0/G1 phase.
(Yano H, Mizoguchi A, Fukuda K, Haramaki M, Ogasawara S, Momosaki S,Kojiro M.)
Cancer Research, 54: 448-454 (1994)
Differential regulation of tissue transglutaminase in rat hepatoma cell lines
McA-RH7777 and McA-RH8994: relationship to growth rate and cell death. (Fukuda K, Kojiro M, Chiu J-F) Journal of Cellular
Biochemistry, 54: 67-77 (1994)
Induction of apoptosis by transforming growth factor-b1 in the rat hepatoma
cell line McA-RH7777: a possible association with tissue transglutaminase
expression. (Fukuda K, Kojiro M, Chiu J-F)
Hepatology, 18: 945-953 (1993)
Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma
7777 tissue: apoptosis or necrosis? (Fukuda K, Kojiro
M, Chiu J-F) American Journal of Pathology, 142: 935-946 (1993)
Establishment of two distinct human hepatocellular carcinoma cell lines from
a single nodule showing clonal dedifferentiation of cancer cells. (Yano H,
Iemura A, Fukuda K, Mizoguchi A, Haramaki M, Kojiro
M.) Hepatology, 18: 320-327 (1993)
A tumor-associated 120 kDa nuclear protein: charactrization using a
monoclonal antibody and a partial cDNA clone. (Fukuda
K, Chiu J-F) International Journal of Biochemistry, 25: 183-200
(1993)
Cross-linked cytokeratin polypeptides in liver and hepatoma cells; possible
association with the process of cell degeneration and death. (Fukuda K, Kojiro M, Chiu J-F) Hepatology, 17: 118-124
(1993)
Apoptosis in human hepatoma xenografts in nude mice. (Fukuda K, Yano H, Kojiro M) International Hepatology
Communications, 1: 83-90 (1993)
Demonstration of cross-linked cytokeratin polypeptides in transplantable rat
hepatoma cells. (Fukuda K, Xie R, Chiu J-F) Biochem.
Biophys. Res. Commun., 176: 441-446 (1991)
Structural alterations in fibronectins secreted from 4 human hepatoma cell
lines: demonstration of hepatoma-associated alternative splicing of mRNA
precursors. (Fukuda K) The Kurume Medical Journal,
38: 233-241 (1991)
Bidirectional morphological changes induced by dexamethasone in Morris
hepatoma cell lines McA-RH7777 and McA-RH8994: independence of fibronectin and
its receptor. (Fukuda K, Xie R, Chiu J-F)
Experimental Cell Research, 195: 207-213 (1991)
Association of fibronectin-like antigens in chromatin preparations from rat
hepatoma cells.(Fukuda K, Dong J-M, Chiu J-F)
Archives of Biochemistry and Biophysics 283: 401- 408 (1990)
The appearance of hepatoma-associated chromosomal non-histone proteins in rat
liver after a single dose of 3'-MDAB followed by treatment of phenobarbital.
(Dong J-M, Kilianska Z, Fukuda K, Chiu J-F) Cancer
letters , 51: 259-267 (1990)
Pathomorphological study on the extrahepatic portal vein in idiopathic portal
hypertension. (Kage M, Arakawa M, Fukuda K, Kojiro.
M.) Liver, 10: 209-216 (1990)
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